Variable diameter bioreactors
AssigneeLonza Ltd.
InventorsMichael Mietzner, Rajesh Beri, Edward Gunderson
Life of this patent
Estimating the term…
Abstract
A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.
Claims15
A variable diameter bioreactor vessel configured for culturing of live cells or cellular biologic material, comprising:
- (a) a vessel configured to hold a liquid medium and the cells or biologic material;
- and
- (b) an agitator, wherein said vessel has a design such that the base of said vessel is narrower than the top of said vessel,
- wherein said vessel is such that the liquid medium and the cells or biologic material can be increased from a first volume to a second volume within the vessel, and
- wherein the agitator is made using a 3-D printer.
A variable diameter bioreactor vessel configured for mammalian cell production, comprising:
- a vessel configured to hold a liquid medium and biologic material,
- wherein said vessel has a design such that the base of said vessel is narrower than the top of said vessel,
- wherein said vessel is such that the liquid medium and biologic material can be increased from a first volume to a second volume within the vessel, and
- wherein the first vessel has a cross-sectional shape that is non-circular.
A variable diameter bioreactor vessel configured for mammalian cell production, comprising:
- a vessel configured to hold a liquid medium and biologic material,
- wherein said vessel has a design such that the base of said vessel is narrower than the top of said vessel,
- wherein said vessel is such that the liquid medium and biologic material can be increased from a first volume to a second volume within the vessel, and
- wherein the first vessel has a cross-sectional shape that is square.
A variable diameter bioreactor system, comprising:
- (a) a bioreactor vessel having a first diameter and a second diameter such that the diameter of the vessel varies along a height of the vessel, at least from the height of the first diameter to the height of the second diameter;
- (b) at least one agitator disposed within the bioreactor vessel such that the agitator provides desired agitation at a given liquid height of the bioreactor vessel;
- (c) a control system operable to scale up the bioreactor vessel from a first volume to a second volume,
- (d) a sparger,
- (e) a probe port,
- (f) a fill port,
- (g) a condenser,
- (h) a vent filter,
- (i) a foam breaker plate,
- (j) a sample port,
- (k) a level probe, and
- (l) a load cell.
Dependencies are inferred from the claim text.