Stimulus-responsive poly(lactic-co-glycolic)-based polymers and nanoparticles formed therefrom
AssigneeThe Regents of the University of California
InventorsAdah Almutairi, Jason Olejniczak, Minnie Chan
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Abstract
PLGA-based polymers include pendant nucleophiles protected with photocleavable protecting groups. Upon deprotection, the polymers degrade rapidly via intramolecular cyclization into small molecules. The polymer may be formulated as a nanoparticle, with an encapsulated payload, which may be an imaging agent, a bioactive agent or a pharmaceutical agent.
Claims19
A composition comprising a polymer having a poly(lactide-co-glycolide) backbone and pendant nucleophiles protected by a stimulus-responsive protecting group, wherein the polymer comprises
- or a derivative thereof, where X is NH, O or S, and wherein the protecting group is configured to deprotect upon exposure to a stimulus to facilitate degradation by intramolecular cyclization.
A composition comprising a polymer comprising:
- a polymer backbone comprising a poly(lactide-co-glycolide) comprising
- or a derivative thereof, where X is NH, O or S, and;
- pendant nucleophiles linked to the backbone and protected by a photolabile protecting group, wherein the protecting group is configured to deprotect upon exposure to irradiation to facilitate degradation of the nucleophiles to five membered rings by intramolecular cyclization.
Dependencies are inferred from the claim text.