Therapeutic use of mitochondria and combined mitochondrial agent
AssigneesChildren's Medical Center Corporation and Beth Israel, Deaconess Medical Center, Inc.
InventorsJames D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
Life of this patent
Estimating the term…
Abstract
The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
Claims15
A method of delivering an agent to a target site of a human subject, the method comprising administering to the subject a composition comprising isolated viable mitochondria and an agent, to thereby deliver the agent to the target site of the subject, wherein the agent is linked to, attached to, embedded in, or encapsulated by the mitochondria, and the composition is administered into a blood vessel that carries blood to the target site, wherein the agent is 18F-Rhodamine 6G or iron oxide nanoparticle.
A method of delivering an agent to a target site of a human subject, the method comprising administering to the subject isolated viable mitochondria and an agent, to thereby deliver the agent to the target site of the subject, wherein the agent is 18F-Rhodamine 6G or iron oxide nanoparticle and the agent is linked to, attached to, embedded in or encapsulated by the mitochondria.
Dependencies are inferred from the claim text.