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US 10,370,451 B2Granted
Preventive or therapeutic agent for inflammatory disease
AssigneeThe University of Tokyo
InventorsKensuke Miyake, Atsuo Kanno, Yuji Motoi, Masahiro Onji
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Abstract
An object of the present invention is to provide a highly-safe and highly-specific preventive or therapeutic agent for inflammatory diseases targeting a TLR7 or TLR9 molecule. The present invention provides a preventive or therapeutic agent for inflammatory diseases containing an anti-TLR7 antibody or anti-TLR9 antibody.
Claims6
An anti-TLR7-antibody (anti-Toll-like receptor 7) selected from the group consisting of:
- (i) an antibody containing a heavy chain CDR1 having the amino acid sequence represented by SEQ ID NO:
- 3, a heavy chain CDR2 having the amino acid sequence represented by SEQ ID NO:
- 4, a heavy chain CDR3 having the amino acid sequence represented by SEQ ID NO:
- 5, a light chain CDR1 having the amino acid sequence represented by SEQ ID NO:
- 6, a light chain CDR2 having the amino acid sequence represented by SEQ ID NO:
- 7, and a light chain CDR3 having the amino acid sequence represented by SEQ ID NO:
- 8;
- and
- (ii) an antibody containing a heavy chain having the amino acid sequence represented by SEQ ID NO:
- 9 and a light chain having the amino acid sequence represented by SEQ ID NO:
- 10.
8 more elements
Dependencies are inferred from the claim text.