Anti-DR6 antibodies and methods of immune regulation

A method for regulating IL-2 production by T cells expressing Death Receptor 6 in a mammal, comprising administering to the mammal an effective amount of a physiologically active substance,

• wherein the physiologically active substance is one or more anti-Death Receptor 6 antibodies selected from the group consisting of the following (a) to (g) and functional fragments thereof:
• (a) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 14, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 16, a heavy chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 18, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 20, a light chain CDR2 consisting of the amino acid sequence of Trp-Ala-Ser, and a light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 22,
• (b) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 24, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 26, a heavy chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 28, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 30, a light chain CDR2 consisting of the amino acid sequence of Tyr-Ala-Ser, and a light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 32,
• (c) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 34, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 36, a heavy chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 38, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 40, a light chain CDR2 consisting of the amino acid sequence of Trp-Ala-Ser, and a light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 42,
• (d) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 44, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 46, a heavy chain CDR3 consisting of the amino add sequence represented by SEQ ID NO:
• 48, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 50, a light chain CDR2 consisting of the amino acid sequence of Trp-Ala-Ser, and a light chain CDR3 consisting of the amino add sequence represented by SEQ ID NO:
• 52,
• (e) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 54, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 56, a heavy chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 58, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 60, a light chain CDR2 consisting of the amino acid sequence of Trp-Ala-Ser, and a light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 62,
• (f) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 64, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 66, a heavy chain CDR3 consisting of the amino add sequence represented by SEQ ID NO:
• 68, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 70, a light chain CDR2 consisting of the amino acid sequence of Arg-Val-Ser, and a light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 72, and
• (g) an anti-Death Receptor 6 antibody comprising a heavy chain CDR1 consisting of the amino add sequence represented by SEQ ID NO:
• 74, a heavy chain CDR2 consisting of the amino acid sequence represented by SEQ ID NO:
• 76, a heavy chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 78, a light chain CDR1 consisting of the amino acid sequence represented by SEQ ID NO:
• 80, a light chain CDR2 consisting of the amino acid sequence of Trp-Ala-Ser, and a light chain CDR3 consisting of the amino acid sequence represented by SEQ ID NO:
• 82.