Methods for treating skin infection by administering an IL-4R antagonist

A method for treating, preventing or ameliorating a skin infection comprising:

• a) selecting a patient with moderate-to-severe atopic dermatitis and having a microbial infection;
• and b) administering a pharmaceutical composition comprising a therapeutically effective amount of an interleukin-4 receptor (IL-4R) antagonist to the patient in need thereof, wherein the IL-4R antagonist is an antibody or antigen-binding fragment thereof that specifically binds IL-4Rα;
• wherein the antibody or antigen-binding fragment thereof comprises three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) of a heavy chain variable region (HCVR) comprising SEQ ID NO:
• 1, and three light chain CDRs (LCDR1, LCDR2 and LCDR3) of a light chain variable region (LCVR) comprising SEQ ID NO:
• 2;
• and wherein the IL-4R antagonist is administered at a dose of 75-600 mg.