Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor

An isolated nucleic acid that hybridizes, under stringent conditions, with the complement of a nucleic acid encoding a polypeptide comprising a sequence selected from the group consisting of SEQ ID NOs:

• 34-42, or a sequence with at least about 95% homology to a nucleic acid encoding a polypeptide comprising a sequence selected from the group consisting of SEQ ID NOs:
• 34-42, wherein the polypeptide
• is an isolated antibody or an antigen-binding fragment thereof
• binds to a PD-L1 protein comprising the amino acid sequence of SEQ ID NO:
• 4;
• and
• is chimeric, humanized, composite, or human.

An isolated nucleic acid encoding a polypeptide, wherein the polypeptide

• is an isolated antibody or an antigen-binding fragment thereof;
• binds to a PD-L1 protein comprising the amino acid sequence of SEQ ID NO:4;
• is chimeric, humanized, composite, or human;
• and
• comprises a sequence selected from the group consisting of SEQ ID NOs:
• 34-42, or a sequence with at least about 95% homology to a sequence selected from the group consisting of SEQ ID NOs:
• 34-42.