Anti-pseudomonas Psl binding molecules and uses thereof
AssigneeMedImmune, LLC
InventorsAntonio Digiandomenico, Paul G. Warrener, Charles K. Stover, Bret Sellman, Sandrine Guillard, Ralph Minter, Steven Rust, Mladen Tomich
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Abstract
The disclosure relates to an anti-Pseudomonas PSL binding molecule and uses thereof, in particular, in prevention and treatment of Pseudomonas infection. Furthermore, the disclosure provides compositions and methods for preventing and treating Pseudomonas infection.
Claims5
A method of blocking attachment of Pseudomonas aeruginosa to epithelial cells comprising contacting a mixture of epithelial cells and P. aeruginosa with an antibody or antigen-binding fragment thereof, wherein the antibody or antibody-binding fragment thereof comprises a set of complementarity determining regions (CDRs) VHCDR1, VHCDR2, VHCDR3, VLCDR1, VLCDR2, and VLCDR3, wherein:
- VHCDR1 comprises SEQ ID NO:
- 47,
- VHCDR2 comprises SEQ ID NO:
- 48,
- VHCDR3 comprises SEQ ID NO:
- 75,
- VLCDR1 comprises SEQ ID NO:
- 50,
- VLCDR2 comprises SEQ ID NO:
- 51, and
- VLCDR3 comprises SEQ ID NO:
- 52.
Dependencies are inferred from the claim text.