Methods of treatment using CTLA4 mutant molecules
AssigneeBristol-Myers Squibb Company
InventorsRobert James Peach, Joseph Naemura, Peter S. Linsley, Jurgen Bajorath
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Abstract
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
Claims10
A method for inhibiting graft versus host disease in a subject which comprises administering to the subject a soluble CTLA4 mutant molecule comprising an extracellular domain as shown in SEQ ID NO:6 beginning with alanine at position 26 or methionine at position 27 and ending with aspartic acid at position 150.
A method for inhibiting graft versus host disease in a subject which comprises administering to the subject a soluble CTLA4 mutant molecule comprising the amino acid sequence shown in SEQ ID NO:6 beginning with alanine at position 26 or methionine at position 27 and ending with lysine at position 383.
Dependencies are inferred from the claim text.