Designer osteogenic proteins
AssigneeWyeth
InventorsJohn Wozney, Howard Seeherman, Christopher Todd Brown
Life of this patent
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Abstract
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
Claims13
A composition comprising a designer bone morphogenetic protein (BMP) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14 and SEQ ID NO:15 and a carrier.
A kit comprising a designer bone morphogenetic protein (BMP) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:15 and combinations thereof.
Dependencies are inferred from the claim text.