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US 10,370,420 B2Granted
Genetically encoded photocleavable proteins
OwnerRobert Campbell, Wei Zhang +1inventors
InventorsRobert Campbell, Wei Zhang, Hiofan Hoi
Life of this patent
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Abstract
Genetically encoded, photocleavable proteins are derived from a fluorescent protein. Upon illumination, the proteins photocleave and spontaneously dissociate into two or more fragments or release one end of an internal loop.
Claims8
A photocleavable protein comprising a His-Tyr-Gly chromophore, which protein comprises a circular permutation of the amino acid sequence of SEQ ID. NO. 17, comprising or consisting of an amino acid sequence selected from SEQ ID NO:
- 2, 4, 6, 8, 10, 12, 14, or 16 or a substantially similar amino acid sequence wherein the protein has at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity thereto, and is photocleavable and dissociates into at least two fragments, or releases one end of a loop insertion.
Dependencies are inferred from the claim text.