Tuberculosis vaccine compositions and related methods
AssigneeThe Board of Regents of the University of Textas System
InventorJianjun Sun
Life of this patent
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Abstract
Compositions and methods directed to ESAT-6 variants which serve as vaccines for the prevention and prophylactic treatment of TB.
Claims16
A Mycobacterium tuberculosis variants with mutations in the 6-kDal early secreted antigenic target (ESAT-6) protein, wherein the M. tuberculosis exhibits attenuated virulence in a mammal when compared to the M. tuberculosis with wild type ESAT-6, wherein the ESAT-6 protein variant comprises a glutamine to lysine or arginine substitution at the amino acid position corresponding to position 5 (Q5K) or (Q5R) of SEQ 1D NO:
- 1.
A mycobacterium in the Mycobacterium tuberculosis complex, genetically engineered to express ESAT-6 protein comprising glutamine to lysine or arginine substitution at an amino acid position corresponding to position 5, (Q5K) or (Q5R) of SEQ 1D NO:
- 1.
A mycobacterium ESAT-6 protein comprising glutamine to lysine or arginine substitution at an amino acid position corresponding to position 5 (Q5K) or (Q5R) of SEQ 1D NO:
- 1.
Dependencies are inferred from the claim text.