Divalent nucleobase compounds and uses therefor
AssigneeCarnegie Mellon University
InventorsDanith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
Life of this patent
Estimating the term…
Abstract
Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
Claims47
A genetic recognition reagent comprising a plurality of nucleobase residues attached to a nucleic acid or nucleic acid analog backbone, in which at least one nucleobase residue is a divalent nucleobase chosen from the following:
- in which each instance of R1 is, independently, a protecting group or H and X is CH or N.
A monomer for production of a genetic recognition reagent comprising a backbone monomer for a genetic recognition reagent covalently attached to a divalent nucleobase chosen from the following:
- in which each instance of R1 is, independently, a protecting group or H and X is CH or N.
A nucleobase chosen from one the following:
- in which each instance of R1 is, independently a protecting group or H, R is a reactive group and X is CH or N.
A genetic recognition reagent comprising a plurality of nucleobase residues attached to a peptide nucleic acid backbone, in which at least one nucleobase is
- where R1 is a protecting group, or H.
Dependencies are inferred from the claim text.