Binding proteins comprising at least two repeat domains against HER2
AssigneeMolecular Partners AG
InventorsUlrike Fiedler, Ignacio Dolado, Heike Strobel
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Abstract
The present invention relates to a recombinant binding protein comprising at least a first and a second repeat domain, wherein each of said two repeat domains binds the extracellular region of HER2 and wherein said repeat domains are covalently linked.
Claims23
A recombinant protein comprising at least a first and a second ankyrin repeat domain, wherein each of said first and second ankyrin repeat domains binds the extracellular region of human epidermal growth factor receptor 2 (HER2), wherein said first ankyrin repeat domain binds domain II of HER2 and said second ankyrin repeat domain binds domain IV of HER2, wherein said first and second ankyrin repeat domains are located on the same polypeptide and wherein said first ankyrin repeat domain is located N-terminally to said second ankyrin repeat domain, and wherein
- a) said first ankyrin repeat domain comprises an amino acid sequence that has at least 91% amino acid sequence identity with an ankyrin repeat domain selected from the group consisting of SEQ ID NOs:62 to 68, 72, and 114 to 121, and
- b) said second ankyrin repeat domain comprises an amino acid sequence that has at least 91% amino acid sequence identity with an ankyrin repeat domain selected from the group consisting of SEQ ID NOs:74 to 82.
A recombinant protein comprising at least a first and a second ankyrin repeat domain, wherein each of said two repeat domains binds the extracellular region of human epidermal growth factor receptor 2 (HER2), wherein said repeat domains are covalently linked, and wherein said recombinant protein comprises a polypeptide, wherein said polypeptide has at least 90% amino acid sequence identity with a polypeptide selected from the group consisting of SEQ ID NO:83 to 98, 102, 103, 122, 123, and 136 to 141.
A recombinant protein comprising at least a first and a second ankyrin repeat domain, wherein each of said two repeat domains binds the extracellular region of human epidermal growth factor receptor 2 (HER2), wherein said repeat domains are covalently linked, and wherein said recombinant protein comprises a polypeptide, wherein said polypeptide comprises said first and second ankyrin repeat domains and has at least 90% amino acid sequence identity with SEQ ID NO:
- 87.
Dependencies are inferred from the claim text.