Kv1.3 potassium channel antagonists

A composition comprising a peptide having the amino acid sequence X1-X2-X3-N-V-X4-C-X5-X6-X7-X8-X9C-X10-X11-X12-C-X13-X14-X15-T-G-C-P-X16-X17-K-C-M-N-R-K-C-X18-C-X19-X20-C as set forth in SEQ ID NO:

• 23:
• wherein X1 is selected from the group consisting of T, Q, S, Y and N;
• wherein X2 is selected from the group consisting of I, F, V, A, L and W;
• wherein X3 is selected from the group consisting of I, T, Y, S, V, A and L;
• wherein X4 is selected from the group consisting of K, S, T, Y and R;
• wherein X5 is selected from the group consisting of R, T, K, S and Y;
• wherein X6 is selected from the group consisting of T, G, S, N, I, K, Q, A, V, L and Y;
• wherein X7 is selected from the group consisting of P, S and T;
• wherein X8 is selected from the group consisting of R, K and P;
• wherein X9 is selected from the group consisting of D, Q, N and E;
• wherein X10 is selected from the group consisting of A, Y, I, L, W, S, T, V, L and F;
• wherein X11 is selected from the group consisting of D, R, P, K, E, S, T and Y;
• wherein X12 is selected from the group consisting of P, H, V, I, L and A;
• wherein X13 is selected from the group consisting of R, K, Q and N;
• wherein X14 is selected from the group consisting of K, D, A, R, E, V, L and I;
• wherein X15 is selected from the group consisting of E, Q, A, L, D, N, V and I;
• wherein X16 is selected from the group consisting of Y, N, S, T and Q;
• wherein X17 is selected from the group consisting of A, G, V, I and L;
• wherein X18 is selected from the group consisting of K and R;
• wherein X19 is selected from the group consisting of Y, N, Q, T and S;
• and
• wherein X20 is selected from the group consisting of G, R and K.