Cancer cell-targeting peptide and use thereof
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsByung-Heon Lee, Hyun-Kyung Jung
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Abstract
The present invention relates to a peptide targeting a tumor cell and use of the peptide, and more particularly, to a peptide consisting of SEQ ID NO: 1 to SEQ ID NO: 4 and specifically binding to a tumor cell, a composition including the peptide as an effective ingredient for detecting a tumor cell, a composition including the peptide as an effective ingredient for delivering a drug, and a composition including the peptide as an effective ingredient for imaging. The peptide of the present invention can be used for detection or imaging of a tumor cell in vitro and in vivo by specifically binding to a tumor cell.
Claims10
A peptide targeting a tumor cell, the peptide consisting of any one amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:
- 2.
A method of detecting a tumor cell, the method comprising:
- (a) mixing a peptide targeting the tumor cell with a sample, the peptide consisting of any one amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:
- 4;
- (b) removing the peptide that is unbound or non-specifically bound;
- and
- (c) determining whether or not the peptide is bound and a binding position of the peptide.
A method of selectively delivering a drug to a tumor cell in a subject, comprising:
- preparing a peptide selectively delivering the drug to the tumor cell, the peptide is consisting of any one amino acid sequence selected from the group consisting of SEQ ID NO:
- 3 to SEQ ID NO:
- 4;
- and
- administering the peptide associated with the drug to the subject.
Dependencies are inferred from the claim text.