Salts and polymorphs of SCY-078
AssigneeScynexis, Inc.
InventorYi Zhang
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Abstract
SCY-078 is a glucan synthase inhibitor with antimicrobial activity. Novel salts and polymorph forms of SCY-078 are disclosed herein. The disclosure also relates to pharmaceutical compositions, methods of use, and methods of preparing the novel salts and polymorphs of SCY-078.
Claims37
A method of treating a fungal infection in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising an effective amount of a pharmaceutically acceptable salt of compound 1:
- wherein the pharmaceutically acceptable salt is selected from citrate, hippurate, mesylate, and fumarate, and wherein the pharmaceutically acceptable salt of compound 1 used to prepare the pharmaceutical composition has a water sorption of from 2% to 7% at 25° C. and 80% relative humidity as determined by DVS.
A method of treating a fungal infection in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising an effective amount of a citrate salt of compound 1:
- wherein the citrate salt of compound 1 used to prepare the pharmaceutical composition comprises at least one of Type A, Type B, Type E, Type F, Type M, Type N, Type O, Type Q, Type R, and Type S citrate crystal forms.
Dependencies are inferred from the claim text.