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US 10,370,399 B2Granted
Calicheamicin-antibody-drug conjugates and methods of use
AssigneeGenentech, Inc.
InventorThomas Pillow
Life of this patent
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Abstract
The invention relates generally to a calicheamicin molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody directly conjugated by a disulfide to one or more calicheamicin molecules.
Claims6
A compound of Formula I:
- wherein R is selected from H, —C(O)R′, —C(O)NR1R2, —S(O)2R1, and —S(O)2NR2R1;
- R1 and R2 are independently selected from C1-C6 alkyl and C6-C20 aryl;
- R3 is selected from NO2, Cl, F, CN, CO2H;
- and Br, and q is 0, 1, or 2.
1 more element
A compound of Formula II:
- wherein R is selected from H, —C(O)R′, —C(O)NR1R2, —S(O)2R1, and —S(O)2NR2R1;
- and R1 and R2 are independently selected from C1-C6 alkyl and C6-C20 aryl.
Dependencies are inferred from the claim text.