Hydrogen peroxide-activable, anti-oxidant compounds and methods using same
AssigneesBeth Israel Deaconess Medical Center, Inc., Chonbuk National University Industrial Cooperation Foundation
InventorsPeter M. Kang, Dongwon Lee, Seunggyu Park, Dahee Jeong
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Abstract
The present invention includes 4-(hydroxymethyl)phenylboronic esters, which react with hydrogen peroxide to form 4-hydroxybenzyl alcohol, which is an anti-inflammatory and/or anti-oxidant compound, as well as microparticles and compositions thereof. In certain embodiments, the compositions of the invention may be used to treat or prevent oxidative stress and/or inflammation, including ischemic disease.
Claims8
A method of reducing inflammation associated with ischemic reperfusion injury in a subject, the method comprising administering to the subject an effective amount of a microparticle comprising 4-(hydroxymethyl)phenylboronic ester, wherein the boronic ester comprises an alcohol selected from the group consisting of a diol, triol, tetraol, pentaol, hexaol and a higher polyol, wherein the alcohol and 4-(hydroxymethyl)phenylboronic acid are covalently conjugated to form the boronic ester, wherein the microparticle comprises a polymer or liposome, thereby reducing inflammation associated with ischemic reperfusion injury relative to a reference.
Dependencies are inferred from the claim text.