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US 10,370,381 B2Granted
Inhibitors of bruton'S tyrosine kinase
AssigneeGilead Sciences, Inc.
InventorBing Shi
Life of this patent
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Abstract
Provided are forms of 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one, compositions thereof, methods for their preparation, and methods for their use.
Claims32
A crystalline hemisulfate, oxalate, hemiedisylate, edisylate, heminapadisylate, fumarate, or succinate of Compound (I):
A process for making a crystalline hemisulfate, oxalate, hemiedisylate, edisylate, heminapadisylate, fumarate, or succinate of Compound (I):
- wherein the process comprises the steps of:
- combining Compound (I) and sulfuric acid, oxalic acid, ethane-1,2-disulfonic acid, naphthalene-1,5-disulfonic acid, fumaric acid or succinic acid in a suitable solvent to obtain a mixture;
- and
- collecting the crystalline hemisulfate, oxalate, hemiedisylate, edisylate, heminapadisylate, fumarate, or succinate of Compound (I).
1 more element
Dependencies are inferred from the claim text.