Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof
AssigneeSunshine Lake Pharma Co., Ltd.
InventorsYingjun Zhang, Chuanfei Jin, Ji Zhang
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Abstract
The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceutical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease related to orexin receptors.
Claims7
The compound having Formula (III), or a stereoisomer, a tautomer, an N-oxide, a solvate, a pharmaceutically acceptable salt or a prodrug thereof,
- wherein X is —O—, —S—, —NH—, or *—CR9═CR9a—, wherein * refers to an end attached to the benzene ring;
- and
- each R1, R2, R3, R4, R9 and R9a is independently H, D, —CD3, —CN, —NH2, —OH, —NO2, —COOH, —C(═O)NH2, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 hydroxy-substituted alkyl, (C1-6 alkyl)—C(═O)—, (C1-6 alkoxy)—C(═O)—, (C1-6 alkylamino)—C(═O)—, cycloalkyl, heterocyclyl, aryl or heteroaryl.
A compound having one of the following structures or a stereoisomer, a tautomer, an N-oxide, a solvate, a pharmaceutically acceptable salt or a prodrug thereof,
Dependencies are inferred from the claim text.