Acid addition salt of 3-aminoquinuclidine which does not exhibit deliquescence
AssigneeYuki Gosei Kogyo Co., Ltd.
InventorsYukiko Takeda, Tetsuji Noda
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Abstract
A novel acid addition salt of 3-aminoquinuclidine, which is an industrially useful compound as an intermediate of medicines and does not exhibit deliquescence, is provided. In particular, an acid addition salt of 3-aminoquinuclidine selected from the group consisting of racemic 3-aminoquinuclidine, (R)-3-aminoquinuclidine, and (S)-3-aminoquinuclidine, and acid selected from the group consisting of phosphoric acid, sulfuric acid, fumaric acid, terephthalic acid, oxalic acid, p-toluenesulfonic acid, (±)-10-camphorsulfonic acid, and (−)-10-camphorsulfonic acid, is provided.
Claims3
An acid addition salt selected from the group consisting of:
- [1] racemic 3-aminoquinuclidine.sesquiphosphate,
- [2] racemic 3-aminoquinuclidine.monofumarate,
- [3] racemic 3-aminoquinuclidine.monoterephthalate,
- [4] racemic 3-aminoquinuclidine.monooxalate,
- [5] racemic 3-aminoquinuclidine.mono-p-toluenesulfonate, and
- [6] racemic 3-aminoquinuclidine.mono-(±)-10-camphorsulfonate;
- wherein the acid addition salt does not exhibit deliquescence.
An acid addition salt selected from the group consisting of:
- [1] (R)-3-aminoquinuclidine.sesquiphosphate,
- [2] (R)-3-aminoquinuclidine.monosulfate,
- [3] (R)-3-aminoquinuclidine.monofumarate,
- [4] (R)-3-aminoquinuclidine.monoterephthalate,
- [5] (R)-3-aminoquinuclidine.monooxalate,
- [6] (R)-3-aminoquinuclidine.mono-p-toluenesulfonate, and
- [7] (R)-3-aminoquinuclidine.mono-(−)-10-camphorsulfonate;
- wherein the acid addition salt does not exhibit deliquescence.
An acid addition salt selected from the group consisting of:
- [1] (S)-3-aminoquinuclidine.sesquiphosphate,
- [2] (S)-3-aminoquinuclidine.monosulfate,
- [3] (S)-3-aminoquinuclidine.monofumarate,
- [4] (S)-3-aminoquinuclidine.monoterephthalate,
- [5] (S)-3-aminoquinuclidine.monooxalate, and
- [6] (S)-3-aminoquinuclidine.mono-p-toluenesulfonate;
- wherein the acid addition salt does not exhibit deliquescence.
Dependencies are inferred from the claim text.