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US 10,370,353 B2Granted
Antifungal compounds and processes for making
AssigneeMycovia Pharmaceuticals, Inc.
InventorsWilliam J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
Life of this patent
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Abstract
The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
Claims11
A 1.5 hydrate polymorph of a compound of formula 1,
- characterized by at least one of:
- (i) a powdered X-ray diffraction pattern having two or more peaks expressed in degrees 2-theta±0.2° and selected from peaks delineated in the pattern of FIG. 5;
- or
- (ii) a DSC thermogram showing an endotherm at about 85° C.
1 more element
A process to prepare a 1.5 hydrate polymorph of compound 1:
- comprising suspending a compound of formula 1 in a solvent and isolating any solid material.
Dependencies are inferred from the claim text.