Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJuan Jose Marugan, Wei Zheng, Jingbo Xiao, John McKew
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Abstract
The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorder, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.
Claims1
A tocopheryl quinone derivative of formula (I):
- wherein
- R1, R2, and R3 independently are hydrogen, halogen, alkyl, or fluoroalkyl;
- Ra and Rb independently are hydrogen or absent in each repeat;
- X is halogen;
- and
- the dotted line bonds indicate single or double bonds.
Dependencies are inferred from the claim text.