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US 10,370,343 B2Granted
[6,6] Fused bicyclic HDAC8 inhibitors
AssigneeFORMA Therapeutics, Inc.
InventorsXiaozhang Zheng, Pui Yee Ng, Jennifer R. Thomason, Mary-Margaret Zablocki, Bingsong Han, Nicholas Barczak, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., Kenneth W. Bair
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Abstract
The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.
Claims18
A composition comprising a compound selected from:
- or a pharmaceutically acceptable salt thereof.
A composition comprising a compound selected from:
- or a pharmaceutically acceptable salt thereof,
- wherein the compound is obtained by a process comprising a step of treating a compound:
- with hydroxylamine and a first base to form a compound:
- wherein R1 is selected from the group consisting of:
1 more element
A composition comprising a first compound selected from:
- and
- a second compound:
Dependencies are inferred from the claim text.