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US 10,370,342 B2Granted
Toll like receptor modulator compounds
AssigneeGilead Sciences, Inc.
InventorsGregory Chin, Richard L. Mackman, Michael R. Mish, Jeff Zablocki
Life of this patent
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Abstract
This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
Claims13
A compound of Formula I
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is —H, C1-4 alkyl, or C1-4 haloalkyl;
- R2 is C1-6 alkyl or C1-6 haloalkyl;
- Q is CR4;
- R3 and R4 are taken together to form phenyl
- optionally substituted with 1 to 3 R5;
- each R5 is independently halogen, —OH, —NH2, —CN, C1-4 alkyl optionally substituted with 1 to 3 RZ, C1-4 haloalkyl, C1-4 alkoxy, —C(O)OH, —C(O)C1-4 alkyl, —C(O)OC1-4 alkyl, —C(O)NH2, —C(O)NH(C1-4 alkyl), —C(O)N(C1-4 alkyl)2, —N(H)C(O)C1-4 alkyl, —S(O)2C1-4 alkyl, or 5 to 6 membered heteroaryl having 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur optionally substituted with 1 to 3 RZ;
- and
- each RZ is independently —NH2, C1-4 alkyl, halogen, —CN, —OC1-4 alkyl, C1-4 haloalkyl, or —C(O)NH2.
7 more elements
Dependencies are inferred from the claim text.