Xanthurenic acid derivative pharmaceutical compositions and methods related thereto

A pharmaceutical formulation comprising in unit dosage form a therapeutically effective amount of an acid or base salt of a freeze-dried, non-steroidal naturietic compound of formula (I):

• wherein R1, R2, R3, R5, R6 and R7 are independently X3R where R is selected from the group consisting of H, halo;
• optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl and heteroaryl;
• —P(O)(ORa)(ORb) and —NRaRb, where Ra and Rb are independently H, optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl;
• X1, and X3 are independently —C(O)O—, —OC(O)—, —C(O)NH—, —NHC(O)—, OC(O)NH—, —NHC(O)O—, —OS(O)y—, —S(O)y—, —O—, —NHC(O)—, —NHC(O)O—, —S(O)2NH—, a bond or absent;
• where y is an integer from 0 to 3;
• and
• R4 is H, (═O);
• hydroxy;
• or optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl;
• or —P(O)(ORa)(ORb) or NRaRb, where Ra and Rb are independently H, or optionally substituted aliphatic, cycloalkyl or heterocycloalkyl, aryl or heteroaryl;
• X2 is —O— and R8 is an optionally substituted saccharide;
• or X2 is OS(O)y— or S(O)y—, where y is an integer from 0 to 3, and R8 is H or optionally substituted aliphatic;
• and a pharmaceutically acceptable carrier.