Oxindole compounds and pharmaceutical compositions thereof

A compound, or a pharmaceutically acceptable salt thereof, wherein said compound is:

• 3-hydroxy-5-methyl-1-(2,2,2-trifluoroethyl)-3-(3,4,5-trimethoxybenzyl)indolin-2-one;
• 2-((3-hydroxy-5-methyl-1-(4-methylpentyl)-2-oxoindolin-3-yl)methyl)-5-methoxyphenyl isonicotinate;
• 2-((3-hydroxy-5-methyl-1-(4-methylpentyl)-2-oxoindolin-3-yl)methyl)-5-methoxyphenyl acetate;
• 2-((3-hydroxy-5-methyl-1-(4-methylpentyl)-2-oxoindolin-3-yl)methyl)-5-methoxyphenyl 2-methoxyacetate;
• 5-chloro-1-ethyl-3-(2-hydroxy-3-methoxybenzyl)-2-oxoindolin-3-yl isonicotinate;
• 5-chloro-1-ethyl-3-(2-hydroxy-3-methoxybenzyl)-2-oxoindolin-3-yl picolinate;
• 5-chloro-1-ethyl-3-(2-hydroxy-3-methoxybenzyl)-2-oxoindolin-3-yl diethyl phosphate;
• 2-((5-chloro-1-ethyl-3-hydroxy-2-oxoindolin-3-yl)methyl)-6-methoxyphenyl 2-methoxyacetate;
• 2-((5-chloro-1-ethyl-3-hydroxy-2-oxoindolin-3-yl)methyl)-6-methoxyphenyl butyrate;
• 5-chloro-1-ethyl-3-(2-hydroxy-3-methoxybenzyl)-2-oxoindolin-3-yl dimethylcarbamate;
• (1,3-dioxolan-4-yl)methyl (5-chloro-1-ethyl-3-(2-hydroxy-3-methoxybenzyl)-2-oxoindolin-3-yl) carbonate;
• 5-chloro-1-ethyl-3-(2-(((2-(2-hydroxyethoxy)ethyl)carbamoyl)oxy)-3-methoxybenzyl)-2-oxoindolin-3-yl benzoate;
• 2-((5-chloro-1-ethyl-2-oxoindolin-3-yl)methyl)-6-methoxyphenyl dimethylcarbamate;
• 3-hydroxy-1,5-dimethyl-3-((1-methyl-1H-indazol-4-yl)methyl)indolin-2-one;
• 1-butyl-3-((1-methyl-1H-indazol-4-yl)methyl)-2-oxoindolin-3-yl benzoate;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-5-chloro-2-oxo-1-propylindolin-3-yl benzoate;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-1-ethyl-3-hydroxy-5-methylindolin-2-one;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-1-butyl-3-hydroxyindolin-2-one;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-3-hydroxy-1-isobutylindolin-2-one;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-1-isopentyl-2-oxoindolin-3-yl benzoate;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-1-isobutyl-5-methyl-2-oxoindolin-3-yl benzoate;
• 3-(benzo[d][1,3]dioxol-4-ylmethyl)-1-isopentyl-5-methyl-2-oxoindolin-3-yl benzoate;
• 3-((1H-benzo[d]imidazol-4-yl)methyl)-5-chloro-1-ethyl-3-hydroxyindolin-2-one,
• 1-ethyl-3-(2-hydroxy-3,4-dimethoxybenzyl)-5-methyl-2-oxoindolin-3-yl dimethylcarbamate;
• 3-((1-benzoyl-1H-indol-3-yl)methyl)-2-oxo-1-propylindolin-3-yl dimethylcarbamate;
• 3-((1H-benzo[d]imidazol-4-yl)methyl)-5-chloro-1-methyl-2-oxoindolin-3-yl dimethylcarbamate;
• 5-chloro-1-ethyl-3-(pyrimidin-4-ylmethyl)indolin-2-one;
• 5-methyl-1-ethyl-3-(pyrimidin-4-ylmethylene)indolin-2-one;
• 5-chloro-1-ethyl-3-hydroxy-3-(pyrazin-2-ylmethyl)indolin-2-one;
• 1-ethyl-5-methyl-3-(pyrazin-2-ylmethylene)indolin-2-one;
• 1-propyl-3-(pyridazin-3-ylmethyl)indolin-2-one;
• N-(5-chloro-2-oxo-1-propyl-3-(pyridazin-3-ylmethyl)indolin-3-yl)nicotinamide;
• 3-((1H-benzo[d]imidazol-2-yl)methylene)-5-chloro-1-ethylindolin-2-one;
• 5-chloro-3-hydroxy-1-propyl-3-(pyrazin-2-ylmethyl)indolin-2-one;
• 5-chloro-3-hydroxy-1-methyl-3-(pyridin-4-ylmethyl)indolin-2-one;
• 5-chloro-3-hydroxy-1-propyl-3-(pyridazin-4-ylmethyl)indolin-2-one;
• 3-hydroxy-1-methyl-3-(pyridin-4-ylmethyl)indolin-2-one;
• (E)-3-((11H-benzo[d]imidazol-2-yl)methylene)-5-chloro-1-methylindolin-2-one;
• N-(3-((1H-benzo[d]imidazol-2-yl)methyl)-1-methyl-2-oxoindolin-3-yl)nicotinamide;
• 1-ethyl-3-hydroxy-3-(pyridazin-3-ylmethyl)indolin-2-one;
• 1-ethyl-5-methyl-3,3-bis(pyridazin-4-ylmethyl)indolin-2-one;
• 1-propyl-3,3-bis(pyridazin-4-ylmethyl)indolin-2-one;
• 1-ethyl-3-hydroxy-5-methyl-3-(pyridazin-3-ylmethyl)indolin-2-one;
• N-(3-((1H-benzo[d]imidazol-2-yl)methyl)-5-chloro-1-ethyl-2-oxoindolin-3-yl)isonicotinamide;
• 3-(benzo[d]oxazol-2-ylmethylene)-5-chloro-1-methylindolin-2-one;
• N-(3-((1H-benzo[d]imidazol-2-yl)methyl)-5-chloro-2-oxo-1-propylindolin-3-yl)benzamide;
• 1-methyl-3-(oxazolo[4,5-b]pyridin-2-ylmethylene)indolin-2-one;
• 5-chloro-2-oxo-1-(2-(piperidin-1-yl)ethyl)-3-(pyridin-2-ylmethyl)indolin-3-yl dimethylcarbamate;
• N-(3-((3-methoxypyridin-2-yl)methyl)-2-oxo-1-propylindolin-3-yl)benzamide;
• N-(5-chloro-1-ethyl-2-oxo-3-(pyridin-2-ylmethyl)indolin-3-yl)-4-methylbenzenesulfonamide;
• 3-(1-ethyl-5-methyl-3-((1-methyl-1H-indazol-4-yl)methyl)-2-oxoindolin-3-yl)-1,1-dimethylurea;
• 1,1-dimethyl-3-(3-((1-methyl-1H-indazol-4-yl)methyl)-2-oxo-1-propylindolin-3-yl)urea;
• 3-(3-(benzo[d][1,3]dioxol-4-ylmethyl)-2-oxo-1-propylindolin-3-yl)-1,1-dimethylurea;
• 3-(3-(benzo[d][1,3]dioxol-4-ylmethyl)-5-chloro-1-methyl-2-oxoindolin-3-yl)-1,1-dimethylurea;
• 3-(3-(benzo[d][1,3]dioxol-4-ylmethyl)-5-chloro-2-oxo-1-propylindolin-3-yl)-1,1-dimethylurea;
• 3-(1,5-dimethyl-2-oxo-3-(3,4,5-trimethoxybenzyl)indolin-3-yl)-1,1-dimethylurea;
• 3-(1-ethyl-2-oxo-3-(3,4,5-tri methoxybenzyl)indolin-3-yl)-1,1-dimethylurea;
• 3-(3-((1-benzoyl-1H-indol-3-yl)methyl)-1-ethyl-2-oxoindolin-3-yl)-1,1-dimethylurea;
• 3-(3-((1-benzoyl-1H-indol-3-yl)methyl)-1-methyl-2-oxoindolin-3-yl)-1,1-dimethylurea;
• 3-(3-((1-benzoyl-1H-indol-3-yl)methyl)-2-oxo-1-propylindolin-3-yl)-1,1-dimethylurea;
• 3-(3-((1-benzoyl-1H-indol-3-yl)methyl)-5-methyl-2-oxo-1-propylindolin-3-yl)-1,1-dimethylurea;
• or
• 2-((5-chloro-1-ethyl-3-hydroxy-2-oxoindolin-3-yl)methyl)-6-methoxyphenyl dimethylsulfamate.