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US 10,370,324 B2Granted
Phenyl and pyridinyl hydroxamic acids
AssigneeAcetylon Pharmaceuticals, Inc.
InventorsJohn H. van Duzer, Ralph Mazitschek
Life of this patent
Estimating the term…
Abstract
The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the treatment of various diseases, disorders, or conditions related to HDAC6.
Claims10
The compound of Formula I:
- or a pharmaceutically acceptable salt thereof;
- wherein
- R is N;
- R1 is H or C1-C3 alkyl;
- R2 and R3 are H;
- or
- R2 is H and R3 is phenyl, wherein the phenyl ring is optionally and independently substituted with 1, 2, or 3 halo, C1-C6 alkyl or C1-C6 alkoxy groups;
- or
- R2 and R3 are taken together to form a C3-C6 cycloalkyl ring or a C2-C5 heterocycloalkyl ring;
- and
- R4 is phenyl, wherein the phenyl ring is optionally and independently substituted with 1, 2, or 3 halo, C1-C6 alkyl or C1-C6 alkoxy groups.
8 more elements
A compound selected from the group consisting of:
- or pharmaceutically acceptable salts thereof.
A compound of Formula Ia:
- or a pharmaceutically acceptable salt thereof;
- wherein
- R is C(H);
- R1 is H or C1-C3 alkyl;
- R2 and R3 are H;
- or
- R2 and R3 are taken together to form a C3-C6 cycloalkyl ring or a C2-C5 heterocycloalkyl ring;
- and
- R4 is phenyl, wherein the phenyl ring is optionally and independently substituted with 1, 2, or 3 halo, C1-C6 alkyl or C1-C6 alkoxy groups.
6 more elements
Dependencies are inferred from the claim text.