Method for preparing chiral gamma-secondary amino alcohol

A method for preparing a chiral γ-secondary amino alcohol, comprising the steps of:

• adding into a solvent an acid addition salt of β-secondary amino ketone represented by the general formula (1), an alkali, a metal salt additive and a diphosphine-rhodium complex to react in hydrogen atmosphere, so as to obtain a chiral compound of γ-secondary amino alcohol represented by the general formula (2),
• in the general formulas (1) and (2), Ar represents an aryl group with or without substituent group(s), R represents an alkyl group or an aralkyl group, and HY represents an acid;
• and
• wherein:
• the diphosphine-rhodium complex is [Rh(L)(L′)]X, wherein
• L is any one chiral diphosphine ligand selected from the group consisting of (R,R)-QuinoxP*, (R,R)-BenzP*, (R,R)-Miniphos, (S,S)-Bi sP*, (S,S)-QuinoxP*, (S,S)-BenzP*, (S,S)-Miniphos and (R,R)-BisP* shown as follows,
• L′ is any one auxiliary diene ligand selected from the group consisting of 1,5-cyclooctadiene and 2,5-norbornadiene,
• X is any one anion selected from the group consisting of SbF6−and BF4−.