Portable and low-error DNA-based data storage

A system comprising:

• a nanopore-based storage device storing a plurality of nucleotide sequence blocks, wherein each of the nucleotide sequence blocks contains respective address sequences followed by data sequences, wherein each of the data sequences as stored is identical to that of a target nucleotide data sequence, wherein each of the data sequences contains a series of fixed-length substrings and each of the fixed-length substrings is 50% guanine and cytosine and 50% adenine and thymine, and wherein reading from the nanopore-based storage device introduces deletion, insertion, or substitution errors into the nucleotide sequence blocks;
• and
• a computing device including a memory storing program instructions that, upon execution by a processor, cause the computing device to perform operations comprising:
• obtaining the plurality of nucleotide sequence blocks read from the nanopore-based storage device;
• selecting a first group of the nucleotide sequence blocks, each having address sequences without any deletion, insertion, or substitution errors;
• aligning the data sequences from the first group of nucleotide sequence blocks with one another;
• and
• performing a first consensus procedure over respective aligned nucleotides of the data sequences from the first group of nucleotide sequence blocks, wherein the first consensus procedure produces a first output nucleotide data sequence.

An article of manufacture including a non-transitory computer-readable medium, having stored thereon program instructions that, upon execution by a computing device, cause the computing device to perform operations comprising:

• obtaining, from a nanopore-based storage device, a plurality of nucleotide sequence blocks, wherein each of the nucleotide sequence blocks as stored in the nanopore-based storage device contains respective address sequences followed by data sequences, wherein each of the data sequences as stored is identical to that of a target nucleotide data sequence, wherein each of the data sequences contains a series of fixed-length substrings and each of the fixed-length substrings is 50% guanine and cytosine and 50% adenine and thymine, and wherein reading from the nanopore-based storage device introduces deletion, insertion, or substitution errors into the nucleotide sequence blocks;
• selecting a first group of the nucleotide sequence blocks, each having address sequences without any deletion, insertion, or substitution errors;
• aligning the data sequences from the first group of nucleotide sequence blocks with one another;
• and
• performing a consensus procedure over respective aligned nucleotides of the data sequences from the first group of nucleotide sequence blocks, wherein the consensus procedure produces a first output nucleotide data sequence.