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US 10,369,360 B2Granted
Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
AssigneeNorthwestern University
InventorsRishi Arora, Alan Kadish, Jason Ng
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Abstract
The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.
Claims3
A method of treating atrial fibrillation in a subject and monitoring the effectiveness of treatment comprising:
- (a) inserting a device into the subject, the device comprising:
- (i) an elongate member with a proximal end, a distal tip, and an inner lumen,
- (ii) an energy-delivery element located at the distal tip of the elongate member, comprising first and second electrodes, and
- (iii) an electrophysiology monitoring element;
- (b) positioning the distal tip of the elongate member at a treatment site on an epicardial or endocardial surface;
- (c) delivering a nucleic acid gene therapy agent to the treatment site through the inner lumen of the elongate member;
- (d) electroporating the treatment site with the first and second electrodes;
- and
- (e) recording intracardiac electrophysiologic activity with the electrophysiology monitoring element after delivering the nucleic acid gene therapy agent to the treatment site.
6 more elements
Dependencies are inferred from the claim text.