Multipart fluid system and a system for citrate anticoagulation in an extracorporeal blood circuit

A multipart fluid system for dialysis therapy, the multipart fluid system comprising:

• an anticoagulation fluid;
• and
• at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids, wherein the anticoagulation fluid comprises 15-40 mM citrate, the at least one treatment fluid comprises 1.5-8 mM citrate and >10 mM bicarbonate, and wherein a level of the bicarbonate in the at least one treatment fluid is selected from a set of bicarbonate levels that satisfy a relationship in which the level of the bicarbonate is decreased with increased citrate levels in the anticoagulation fluid.