Method for modifying surfaces for better osseointegration
AssigneeThe University of Toledo
InventorsSarit B. Bhaduri, Vijay K. Goel, Huan Zhou
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Abstract
In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
Claims13
A method for preparing a biocompatible coated substrate comprising:
- pretreating at least a portion of a substrate by etching the substrate with NaOH so as to activate a surface of the portion of the substrate, wherein the portion of the substrate comprises a polymeric material comprising polyetheretherketone (PEEK);
- exposing the surface to a solution mixture comprising at least calcium and phosphate ions at a Ca/P molar ratio of from about 1 to about 2.5, wherein the calcium and phosphate ions are present in the solution mixture at a concentration on the order of a millimolar concentration;
- exposing the solution mixture and the portion of the substrate to microwave energy for a time sufficient to form a calcium phosphate (CaP) layer having a thickness of about 15 μm or less on the surface, wherein the sufficient time is about 1 hour or less;
- and
- keeping the substrate in ethanol for a period of time to stabilize the CaP layer on the surface.
Dependencies are inferred from the claim text.