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US 10,369,240 B2Granted
Targeted enzymatic degradation of quorum-sensing peptides
AssigneeKCI Licensing, Inc.
InventorsRodolfo M. Alarcon, Amy K. McNulty
Life of this patent
Estimating the term…
Abstract
Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.
Claims20
A dressing for treating a wound, comprising:
- a distribution manifold comprising collagen;
- and
- a bifunctional ligand disposed on a surface of the distribution manifold and comprising a quorum-sensing-molecule-binding region chemically linked to a protease-binding region.
A system for treating a tissue site, comprising:
- a dressing comprising a bioresorbable material and a bifunctional ligand comprising a quorum-sensing-molecule-binding region chemically linked to a protease-binding region;
- a sealing member adapted to be positioned over the dressing and the tissue site to create a sealed environment;
- and
- a reduced-pressure source adapted to be in fluid communication with the sealed environment.
1 more element
A dressing for treating a wound, comprising:
- a carrier material adapted to be positioned on the wound;
- and
- a composition adapted to be applied to the carrier material and comprising:
- a bifunctional ligand comprising a quorum-sensing-molecule-binding region chemically linked to a protease-binding region, and
- a therapeutic agent for treating the wound.
2 more elements
Dependencies are inferred from the claim text.