Nucleic acid products and methods of administration thereof
AssigneeFactor Bioscience Inc.
InventorsMatthew Angel, Christopher Rohde
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Abstract
The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
Claims10
A composition comprising a synthetic RNA encoding a gene-editing protein that targets an immune checkpoint molecule gene, wherein the gene-editing protein comprises:
- (a) a DNA-binding domain comprising a plurality of repeat sequences and at least one of the repeat sequences comprises the amino acid sequence:
- LTPvQVVAIAwxyzGHGG (SEQ ID NO:
- 629) and is between 36 and 39 amino acids long, wherein:
- “v” is Q, D or E,
- “w” is S or N,
- “x” is H, N, or I,
- “y” is D, A, I, N, G, H, K, S, or null, and
- “z” is GGKQALETVQRLLPVLCQD (SEQ ID NO:
- 630) or GGKQALETVQRLLPVLCQA (SEQ ID NO:
- 631);
- and
- (b) a nuclease domain comprising a catalytic domain of a nuclease.
Dependencies are inferred from the claim text.