Back to results
US 10,369,229 B2Granted
Methods and compositions for liposomal formulation of antigens and uses thereof
AssigneesThe Regents of the University of California, Molecular Express, Inc.
InventorsGary Fujii, Francis C. Szoka, Douglas S. Watson
Life of this patent
Estimating the term…
Abstract
The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
Claims11
A composition comprising:
- an aqueous vehicle;
- and
- liposomes comprising
- (i) dimyristoylphosphatidylcholine (“DMPC”),
- (ii) dimyristoylphosphatidylglycerol (“DMPG”), dimyristoyltrimethylammonium propane (“DMTAP”), or both DMPG and DMTAP, and
- (iii) at least one reactive sterol derivative, wherein between 1% and 100% of said at least one sterol derivatives comprise an influenza M2 antigen polypeptide sequence covalently linked thereto.
3 more elements
Dependencies are inferred from the claim text.