Compositions and methods of use of phorbol esters for the treatment of stroke
AssigneeBiosuccess Biotech Co. Ltd.
InventorsZheng Tao Han, Hung-Fong Chen
Life of this patent
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Abstract
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.
Claims10
A method for alleviating or treating one or more of the effects of stroke in a mammalian subject comprising administering parenterally to said subject, an effective amount of phorbol ester of Formula II, or a pharmaceutically-acceptable salt, isomer, or enantiomer, thereof
- wherein the phorbol ester of Formula II is present at an amount from about 10 μg to about 1500 μg, wherein the one or more effects of stroke are paralysis, spatial impairment, impaired judgement, left-sided neglect, memory loss, aphasia, coordination and balance problems, nausea, vomiting, cognitive impairment, perception impairment, orientation impairment, homonymous hemianopsia, impulsivity, or impaired mobility.
A method for reducing symptoms of a stroke comprising administering parenterally, an effective amount of phorbol ester of Formula II, or a pharmaceutically-acceptable salt, isomer, or enantiomer, thereof to a mammalian subject
- wherein the phorbol ester of Formula II is present at an amount from about 10 μg to about 1500 μg, wherein the one or more symptoms comprise sudden numbness, weakness, sudden confusion, trouble speaking or understanding speech, trouble seeing in one or both eyes, trouble walking, dizziness, loss of balance or coordination, sudden headache, or impaired mobility.
Dependencies are inferred from the claim text.