Immunostimulator and method for producing the same
AssigneesHiroshi Handa, Saitama Medical University, Sysmex Corporation
InventorsHiroshi Handa, Masaaki Kawano, Masahiko Kato
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Abstract
Disclosed is an immunostimulator containing virus-like particles, in which the virus-like particles contain an outer coat protein containing an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 26, SEQ ID No. 33, SEQ ID No. 35, SEQ ID No. 37, SEQ ID No. 39, SEQ ID No. 41, SEQ ID No. 43 and SEQ ID No. 45; the outer coat protein constitutes an outer coat of the virus-like particles; and the virus-like particles do not substantially contain a genome DNA of SV40.
Claims4
A method for potentiating an immune effect of a living body, comprising administering an adjuvant and a vaccine comprising an exogenous antigen to a living body and inducing production of CD86+ lymphocytes in the living body, the adjuvant comprising a pharmacologically effective amount of virus-like particles,
- wherein the virus-like particles comprise an outer coat protein comprising the amino acid sequence of SEQ ID NO:
- 1;
- wherein the outer coat protein constitutes an outer coat of the virus-like particles;
- wherein the virus-like particles do not substantially comprise a genome DNA of SV40;
- and
- wherein the virus-like particles do not substantially comprise the exogenous antigen.
A method for potentiating an immune effect of a living body, comprising administering an adjuvant and a vaccine comprising an exogenous antigen to a living body, the adjuvant comprising a pharmacologically effective amount of virus-like particles;
- wherein the virus-like particles comprise an outer coat protein comprising the amino acid sequence of SEQ ID NO:
- 1;
- wherein the virus-like particles do not substantially comprise a genome DNA of SV40;
- and
- wherein the virus-like particles do not substantially comprise the exogenous antigen.
Dependencies are inferred from the claim text.