Immunomodulatory compositions and methods of use thereof
OwnerBabita Agrawal, Rakesh Kumarinventors
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Abstract
The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
Claims12
A method of modulating an antigen-specific immune response in an individual, the method comprising administering to the individual an effective amount of an immunomodulatory composition comprising:
- a) heat-killed Caulobacter crescentus;
- b) a pathogen-derived antigen, or a tumor-associated antigen;
- and
- c) a pharmaceutically acceptable excipient;
- wherein the composition is administered via an oral, nasal, subcutaneous, intramuscular, topical or mucosal route of administration.
A method of reducing tumor progression or an infection in an individual having a disease selected from the group consisting of cancer and an infectious disease, wherein the infectious disease is caused by a virus, a bacterium, a fungus, a parasite, or a mycobacterium, the method comprising administering to the individual a composition comprising:
- a) heat-killed Caulobacter crescentus;
- and
- b) a pharmaceutically acceptable excipient;
- wherein the composition is administered via an oral, nasal, subcutaneous, intramuscular, topical or mucosal route of administration.
A method of enhancing the efficacy and/or reducing the toxicity of a therapeutic treatment in an individual, the method comprising administering to the individual an effective amount of an immunomodulatory composition comprising:
- a) heat-killed Caulobacter crescentus;
- and
- b) a pharmaceutically acceptable excipient;
- wherein the composition is administered via an oral, nasal, subcutaneous, intramuscular, topical or mucosal route of administration,
- wherein the therapeutic treatment is an anticancer treatment.
Dependencies are inferred from the claim text.