Molecular vaccines for infectious disease

An immunogenic composition for producing an immune response against HIV infection comprising one or more biologically active molecules attached to one or more multimerization domains, which do not include membranes, selected from the group consisting of polymers and solid supports, wherein the one or more biologically active molecules comprise:

• i) one or more MHC class I complexes and/or one or more MHC class II complexes attached to the one or more multimerization domains, each optionally loaded with a peptide epitope to form one or more MHC class I-peptide complexes and/or one or more MHC class II-peptide complexes;
• and, separately,
• ii) one or more HIV-derived proteins attached to the one or more multimerization domains, wherein said HIV-derived proteins are each selected from the group consisting of gp41, gp120, gp140, gp27, and recombinant forms thereof.