Crystallized oxalate decarboxylase and methods of use
AssigneeAllena Pharmaceuticals, Inc.
InventorsBhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
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Abstract
Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
Claims7
A capsule comprising a pharmaceutical composition that comprises spray-dried, biologically active oxalate decarboxylase crystals having a moisture content of less than 5% by weight, and a filler, wherein the oxalate decarboxylase is uncrosslinked and is capable of converting oxalate to formate.
Dependencies are inferred from the claim text.