Methods and compositions for preventing and treating damage to the heart
AssigneesMandalMed, Inc., The Regents of the University of California
InventorsConstance M. John, Meenakshi Gaur, Matthew L. Springer, Xiaoyin Wang
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Abstract
Provided herein are methods and compositions for preventing and treating damage to the heart subsequent to myocardial infarction (MI) resulting from harmful fibrotic remodeling, thereby improving cardiac function and reducing mortality from subsequent heart failure.
Claims19
A method of reducing infarct size following myocardial infarction (MI) in a human subject comprising administering to the subject an effective dose of Galectin-3C (Gal-3C) beginning 4 days post MI, wherein the Gal-3C comprises the amino acid sequence of SEQ ID NO:3, wherein the effective dose of Gal-3C is 0.25 mg per kg to 0.35 mg per kg of body weight of the subject.
A method of reducing infarct size following myocardial infarction (MI) in a human subject, comprising administering to the subject an effective dose of Galectin-3C (Gal-3C) on a daily basis from 14 days to 28 days post MI, wherein the Gal-3C comprises the amino acid sequence of SEQ ID NO:3 and the effective dose of Gal-3C is 0.25 mg per kg to 0.35 mg per kg of body weight of the subject.
Dependencies are inferred from the claim text.