Administration of polynucleotide toll-like receptor 9 agonists for treating cancer
AssigneeDynavax Technologies Corporation
InventorsCristiana Guiducci, Robert L. Coffman
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods for treating cancer by intrapulmonary administration of a polynucleotide Toll-like receptor 9 agonist. The methods of the present disclosure are suitable for treating primary cancer of the lung, as well as metastatic cancer to the lung and extra pulmonary cancers thereof. Additionally, the present disclosure provides polynucleotide Toll-like receptor 9 agonists with immune stimulatory and toxicity profiles suitable for intrapulmonary administration.
Claims23
A method of treating cancer in a mammalian subject in need thereof, the method comprising administering to the subject by injection an effective amount a pharmaceutical composition comprising a pharmaceutically acceptable excipient and an isolated polynucleotide, wherein the polynucleotide is a 2′-deoxyribopolynucleotide consisting of the sequence of:
- 5′-TCGTAACGTTCGAACGTTCGANx-3′ (SEQ ID NO:2), wherein x is 0, 1 or 2, each N is A, C or T, and wherein all internucleotide linkages are phosphorothioate linkages.
Dependencies are inferred from the claim text.