Methods of improving cell-based therapy
AssigneeThe Regents of the University of California
InventorsNipavan Chiamvimonvat, Bruce D. Hammock
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Abstract
Provided are methods for improving cell-based therapies by co-administration with an agent that increases the production and or levels of epoxygenated fatty acids, as well as kits, stents and patches for co-administering stem cells with an agent that increases the production and/or levels of epoxygenated fatty acids.
Claims21
A method of increasing the survival, engraftment and/or integration of transplanted induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) into cardiac tissue of a subject in need thereof, comprising co-administering to the subject the hiPSC-CMs with an agent that increases the production and/or level of epoxygenated fatty acids, wherein the co-administration results in an increase in the survival, engraftment and/or integration of the transplanted hiPSC-CMs relative to administration of the hiPSC-CMs alone.
A method of reversing, mitigating and/or improving one or more symptoms associated with cardiomyopathy or cardiac arrhythmia in an subject in need thereof, said method comprising co-administering to said subject a population of induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and an agent that increases the production and/or level of epoxygenated fatty acids.
Dependencies are inferred from the claim text.