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US 10,369,128 B1Granted
Pharmaceutical composition containing a cis-diamine platinum thione complex
AssigneeKing Fahd University of Petroleum and Minerals
InventorsMohammed Yagoub Jomaa, Anvarhusein A. Isab
Life of this patent
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Abstract
A method for treating a proliferative disease, disorder, or condition comprising administering a cis-diamine platinum(II) thione complex. A cis-diamine platinum(II) thione complex and compositions containing it.
Claims2
A pharmaceutical composition comprising at least one cis-diamine platinum(II) thione complex in combination with at least one pharmaceutically acceptable carrier or excipient,
- wherein the cis-diamine platinum(II) thione complex is at least one selected from the group consisting of:
- cis-[Pt(NH3)2(Imt)2].2NO3(1),
- cis-[Pt(NH3)2(MeImt)2].2NO3(2),
- cis-[Pt(NH3)2(Me2Imt)2].2NO3(3),
- cis-[Pt(NH3)2(Et2Imt)2].2NO3(4),
- cis-[Pt(NH3)2(PrImt)2].2NO3(5),
- cis-[Pt(NH3)2(iPrImt)2].2NO3(6),
- cis-[Pt(NH3)2(iPr2Imt)2].2NO3(7),
- cis-[Pt(NH3)2(Diaz)2].2NO3(8),
- cis-[Pt(NH3)2(EtDiaz)2].2NO3(9), and
- cis-[Pt(NH3)2(Diap)2].2NO3(10),
- wherein Imt is imidazolidine-2-thione, MeImt is N-methylimidazolidine-2-thione, Me2Imt is N,N′-dimethylimidazolidine-2-thione, Et2Imt is N,N′-diethylimidazolidine-2-thione, PrImt is N-propylimidazolidine-2-thione, iPrImt is N-(isopropyl)imidazolidine-2-thione, iPr2Imt is N,N′-(di-isopropyl)imidazolidine-2-thione, Diaz is diazinane-2-thione, and Diap is 1,3-Diazepane-2-thione.
9 more elements
Dependencies are inferred from the claim text.