Method for inhibiting the expression of ABC transporter protein
AssigneeMacau University of Science and Technology
InventorsKam Wai Wong, Yuen Kwan Law, Man Chung Wong
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Abstract
A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an overexpression of the ABC transporter protein includes administrating a cobalt-polypyridyl complex to the subject. A method for inhibiting the expression and/or functional activity of an ABC transporter in cells includes contacting the cells with an effective amount of the cobalt-polypyridyl complex.
Claims15
A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an overexpression of the ABC transporter protein, comprising the step of administering an effective amount of a cobalt-polypyridyl complex of Formula (II) to the subject:
- wherein R1 and R2 are identical and selected from, —CH3, —C9H19 or —OCH3;
- wherein n is 2 or 3;
- and wherein the disorder is selected from the group consisting of breast cancer, lung cancer, and colon cancer.
A method for inhibiting the expression and/or functional activity of an ABC transporter protein in cells by contacting the cells with an effective amount of a cobalt-polypyridyl complex, wherein the cobalt-polypyridyl complex comprises a structure of Formula (II):
- wherein R1 and R2 are identical and selected, —CH3, —C9H19 or —OCH3;
- wherein n is 2 or 3, and wherein the cells are cancer cells and are selected from the group consisting of breast cancer cells, lung cancer cells, and colon cancer cells.
Dependencies are inferred from the claim text.