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US 10,369,122 B2Granted
Benzene-1,3,5-tricarboxamide derivatives and uses thereof
AssigneeOhio State Innovation Foundation
InventorsYizhou Dong, Bin Li
Life of this patent
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Abstract
The present invention relates to compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a polynucleotide).
Claims21
A compound of Formula I:
- and salts thereof;
- wherein
- each R1 is independently unsubstituted alkyl;
- each R2 is independently unsubstituted alkyl;
- each R3 is independently hydrogen or substituted or unsubstituted alkyl;
- and
- each m is independently 3, 4, 5, 6, 7, or 8;
- wherein at least one R1 is unsubstituted C10-12 alkyl.
5 more elements
A nanoparticle comprising:
- a compound of Formula I;
- and salts thereof;
- wherein
- each R1 is independently substituted or unsubstituted alkyl;
- each R2 is independently substituted or unsubstituted alkyl;
- each R3 is independently hydrogen or substituted or unsubstituted alkyl;
- and
- each m is independently 1, 2, 3, 4, 5, 6, 7, or 8;
- a non-cationic lipid;
- a polyethylene glycol-lipid;
- and
- a sterol.
9 more elements
A method for the delivery of an agent into a cell comprising;
- introducing into the cell a composition comprising;
- a nanoparticle comprising;
- a compound of Formula I;
- and salts thereof;
- wherein
- each R1 is independently substituted or unsubstituted alkyl;
- each R2 is independently substituted or unsubstituted alkyl;
- each R3 is independently hydrogen or substituted or unsubstituted alkyl;
- and
- each m is independently 1, 2, 3, 4, 5, 6, 7, or 8;
- a non-cationic lipid;
- a polyethylene glycol-lipid;
- a sterol;
- and
- an agent.
12 more elements
A compound of Formula I:
- and salts thereof;
- wherein
- each R1 is independently substituted or unsubstituted alkyl;
- each R2 is independently substituted or unsubstituted alkyl;
- each R3 is independently hydrogen or substituted or unsubstituted alkyl;
- and
- each m is independently 1, 2, 3, 4, 5, 6, 7, or 8;
- wherein at least one R1 is C12H25.
5 more elements
Dependencies are inferred from the claim text.