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AssigneeUniversity of Virginia Patent Foundation
InventorsLloyd S. Gray, Timothy L. Macdonald, Doris M. Haverstick, Jaclyn R. Patterson, William F. McCalmont
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The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein R1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; Z is NH, NCH3, O, S, or CH2; Y is NH, O, or CH2 with the proviso that Y and Z are not the same; R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; and R3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.
A method for treating a disease or condition selected from the group consisting of hypertension and cardiac arrhythmia in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, wherein the compound has a structure represented by Formula (1):
A method for treating a disease or condition selected from the group consisting of unstable angina, hypertension, epilepsy, neuropathic pain, petit mal seizure, absence seizure, age related, macular degeneration and cancer in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor or a pharmaceutically acceptable salt of said inhibitor, wherein the inhibitor is selected from the group consisting of the following compounds:
Dependencies are inferred from the claim text.