Inhibition of multiple pathogenic agents using bithionol
AssigneeKeck Graduate Institute of Applied Life Sciences
InventorsMikhail Martchenko, William Leonardi
Life of this patent
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Abstract
Compositions and methods including Bithionol are provided for treating, inhibiting, or preventing caspase-dependent pathogenic agents in a host cell or infected subject. Examples of caspase-dependent pathogenic agents include ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof. Compositions and methods also include Bithionol in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.
Claims19
A method of inhibiting a pathogenic agent in a host cell or in a subject, the method comprising administering Bithionol to the host cell or the subject, the pathogenic agent being selected from the group consisting of ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof.
A composition for inhibiting a pathogenic agent in a host cell or a subject, the pathogenic agent being selected from the group consisting of Botulinum neurotoxin A, Bacillus anthracis, Pseudomonas aeruginosa, cholera, diphtheria, Clostridium botulinum and combinations thereof, the composition comprising:
- Bithionol;
- and
- an antibiotic.
A method of inhibiting a caspase-dependent pathogenic agent in a host cell or in a subject, the method comprising administering Bithionol to the host cell or the subject, wherein the caspase-dependent pathogenic agent is selected from the group consisting of ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof.
A composition for inhibiting a caspase-dependent pathogenic agent in a host cell or a subject, the composition comprising:
- Bithionol;
- and
- an antibiotic.
Dependencies are inferred from the claim text.